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WHAT IS NARINGIN? Naringin is a grapefruit flavanoid proported to extend the half life of numerous other drugs, especially caffeine, thus prolonging its thermogenic effect. HOW EXACTLY DOES NARINGIN WORK? Naringin is an inhinbitor of the cytochrome p450 liver enzymes. Of particular interest, one of these enzymes (CYP1A2) is responsible for metabolizing caffeine. Furthermore, some of these enzymes may also appear in the intestinal lining, so naringin may alter the absoprtion of caffeine. In studies naringin combined with caffeine has increased it's half life by 31% and decreased oral clearance of caffeine by 23% meaning that it could substantially prolong the fat burning effects of this compound. APPLICABLE USES OF NARINGIN/COMBINING NARINGIN WITH EPHEDRINE When ephedrine or an equivalent is used (often with caffeine) the body releases a chemical called norepinephrine, a chemical messenger that signals the release of epinephrine. These messengers attach to receptors which cause an enzyme named adenylate cyclase to convert ATP into cAMP for energy. The effect of cAMP can be greatly increased by using Naringin. HOW MUCH SHOULD I USE AND WHEN? An effective dose being 16 - 150 mg 2 - 3 times per day, usually with an ephedrine/caffeine mix.
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