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What is Creatine Ethyl Ester?
Creatine Ethyl Ester HCL (CEE) is creatine monohydrate with an ester attached.
Where Does The Esterification Process Come From?
Esters are organic compounds that are formed by esterification - the reaction
of carboxylic acid and alcohols.
What Are The Benefits of Esterification?
The esterification process dramatically improves the bioavailability of the
creatine molecule. By super-sizing the benefits of creatine supplementation
and greatly down-sizing all of the negatives of creatine monohydrate use (such
as bloating, cramping, and possibly harmful waste by-products, the performance
of the athlete can be greatly enhanced and taken to the very next level.
Nearly everybody knows that regular creatine monohydrate has been shown effective
at increasing lean muscle mass, muscle strength and athletic performance. The
overall effectiveness of monohydrate use is dependant upon the cells ability
to absorb it. The poor absorption rate of regular creatine monohydrate requires
the creatine user to ingest large dosages of creatine to achieve desired effect.
Because creatine draws water to the cell, and because most ingested creatine
monohydrate is not absorbed, unabsorbed creatine will sit outside of the target
cell with the water, and this will result in the "creatine bloat."
This is one of the most famous and least desired side effects of original monohydrate
use.
Long-term clinical studies have proven that creatine monohydrate is safe for
use by persons free of medical complication9, but why would you want to ingest
more creatine monohydrate than you have to simply because your creatine is inefficient?
Creatine ethyl ester is creatine monohydrate with an ester attached. The attachment
of an ester is significant, because esters are found in the fat tissue of animals.
But, why is this important? What role does this have in the absorption of creatine?
All substances that you put into your body will affect its operation. There
are three ways that substances can affect a cells operation. They are:
Ligand binding to protein receptor sites.
Secondary messenger / metabotropic systems
Passive permeation of the cell wall via lipids
When a substance enters the body and affects the bodies operation, it is known
as a ligand. The soma and dendrites of the cell have protein receptor sites
to which ligands can bind. The process of a ligand binding with a receptor site
is akin to a lock and key: only keys of a certain shape work with certain locks.
When they work and cause the cells stimulation they are called agonists. When
they block the cell from functioning they are called antagonists.
When a ligand binds with the receptor site of a target cell, the cell, in the
simplest of cases, changes its shape, opens up its ion channels and changes
its function. In so-called "secondary messenger" or metabotropic cells,
the ligand binds with the receptor site and an internal protein known as a g-protein
is released. This released protein then binds to an internal site inside of
the cell, and then the cell changes its behavior by opening its ion channels.
Cells that operate in this way are known as metabotropic cells because their
operation requires metabolic energy.
Passive permeation is a process that describes the diffusion of a substance
across a cell membrane through the use of lipids as transport mechanisms. Because
no "work" is being done by the cell in this model, this model is called
passive permeation.
Creatine monohydrate utilizes lipids to permeate the cell wall and enter the
cell. Because of this, the esterification of creatine, and the presence of esters
in animal fat tissue, becomes significant.
Creatine monohydrate is semi-lipopholic. This means that it inefficiently uses
fat as a transport mechanism. The esterification of substances will increase
their lipopholic abilities, and thus esterified creatine will use fat more efficiently
to permeate the cell wall and exert its effects upon cellular function than
its unesterified creatine monohydrate counterpart.
This means, simply, that not only will dosage requirements be lower, but the
absorption of esterified creatine will be increased and the infamous "creatine
bloat" will be eliminated! This is a dramatic and much sought after break
thtough in creatine supplementation technology!
Who Will Beneifit From Creatine Ethyl Ester?
Essentially, Creatine Ethyl Ester can benefit persons of all ages, as it displays
the same benefits as regular creatine monohydrate. Any sports person of any
sporting endeavour that benefitted from creatine monohydrate will see and feel
improved resulots by switching to a new creatine ethyl ester compound. Many
multiple sclerosis patients are classified as creatine non-responders, but with
the improved absorption seen with CEE this may not be the case.
How To Take Creatine Ethyl Ester
Similar to Creatine Monohydrate, the recommended dosage of creatine ethyl ester
is of course somewhat influenced by your muscular bodyweight - i.e. the bigger
you are the more you are going to need. The recommended dosage is around 3 -
5 grams per day. With most companies that have brougt a good quality ethyl ester
product to the market - the capsules are around 1g each and so you will be consuming
around 3 - 5 capsules per day. This is best to take with water and around 30
minutes prior to a meal to enhance absorption. There are no immediate benefits
of note to take the product immediately prior to a training session or post
training and likewise no negatives to doing this.
Unlike Monohydrate there is no evidence to suggest that the best thing to do
is to cycle ethylated creatine ester. One could use this supplement long term
without a break although there would probably no benefit to the psychological
boost experienced, when initially supplementing with a creatine product.
As stated, due to the enhance lipopholic absorption of the esterified creatine
there is absolutely no need to load up on this compound.
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