About creatine-ethyl-ester

About creatine-ethyl-ester Author: Technical Panel 27/02/2006
Also Known As:
Creatine
Variations:
Creatine Citrate
Creatine Pyruvate
Tri-Creatine-Malate
Related Items:
Creatine Monohydrate
Creatine Transport Systems
Insulin Hormone
Type:
Energy/Strength Product
Muscle Growth

What is Creatine Ethyl Ester?
Creatine Ethyl Ester HCL (CEE) is creatine monohydrate with an ester attached.

Where Does The Esterification Process Come From?
Esters are organic compounds that are formed by esterification - the reaction of carboxylic acid and alcohols.

What Are The Benefits of Esterification?
The esterification process dramatically improves the bioavailability of the creatine molecule. By super-sizing the benefits of creatine supplementation and greatly down-sizing all of the negatives of creatine monohydrate use (such as bloating, cramping, and possibly harmful waste by-products, the performance of the athlete can be greatly enhanced and taken to the very next level.

Nearly everybody knows that regular creatine monohydrate has been shown effective at increasing lean muscle mass, muscle strength and athletic performance. The overall effectiveness of monohydrate use is dependant upon the cells ability to absorb it. The poor absorption rate of regular creatine monohydrate requires the creatine user to ingest large dosages of creatine to achieve desired effect. Because creatine draws water to the cell, and because most ingested creatine monohydrate is not absorbed, unabsorbed creatine will sit outside of the target cell with the water, and this will result in the "creatine bloat." This is one of the most famous and least desired side effects of original monohydrate use.

Long-term clinical studies have proven that creatine monohydrate is safe for use by persons free of medical complication9, but why would you want to ingest more creatine monohydrate than you have to simply because your creatine is inefficient?

Creatine ethyl ester is creatine monohydrate with an ester attached. The attachment of an ester is significant, because esters are found in the fat tissue of animals. But, why is this important? What role does this have in the absorption of creatine?

All substances that you put into your body will affect its operation. There are three ways that substances can affect a cells operation. They are:

Ligand binding to protein receptor sites.
Secondary messenger / metabotropic systems
Passive permeation of the cell wall via lipids

When a substance enters the body and affects the bodies operation, it is known as a ligand. The soma and dendrites of the cell have protein receptor sites to which ligands can bind. The process of a ligand binding with a receptor site is akin to a lock and key: only keys of a certain shape work with certain locks. When they work and cause the cells stimulation they are called agonists. When they block the cell from functioning they are called antagonists.


When a ligand binds with the receptor site of a target cell, the cell, in the simplest of cases, changes its shape, opens up its ion channels and changes its function. In so-called "secondary messenger" or metabotropic cells, the ligand binds with the receptor site and an internal protein known as a g-protein is released. This released protein then binds to an internal site inside of the cell, and then the cell changes its behavior by opening its ion channels. Cells that operate in this way are known as metabotropic cells because their operation requires metabolic energy.

Passive permeation is a process that describes the diffusion of a substance across a cell membrane through the use of lipids as transport mechanisms. Because no "work" is being done by the cell in this model, this model is called passive permeation.

Creatine monohydrate utilizes lipids to permeate the cell wall and enter the cell. Because of this, the esterification of creatine, and the presence of esters in animal fat tissue, becomes significant.

Creatine monohydrate is semi-lipopholic. This means that it inefficiently uses fat as a transport mechanism. The esterification of substances will increase their lipopholic abilities, and thus esterified creatine will use fat more efficiently to permeate the cell wall and exert its effects upon cellular function than its unesterified creatine monohydrate counterpart.

This means, simply, that not only will dosage requirements be lower, but the absorption of esterified creatine will be increased and the infamous "creatine bloat" will be eliminated! This is a dramatic and much sought after break thtough in creatine supplementation technology!

Who Will Beneifit From Creatine Ethyl Ester?
Essentially, Creatine Ethyl Ester can benefit persons of all ages, as it displays the same benefits as regular creatine monohydrate. Any sports person of any sporting endeavour that benefitted from creatine monohydrate will see and feel improved resulots by switching to a new creatine ethyl ester compound. Many multiple sclerosis patients are classified as creatine non-responders, but with the improved absorption seen with CEE this may not be the case.

How To Take Creatine Ethyl Ester
Similar to Creatine Monohydrate, the recommended dosage of creatine ethyl ester is of course somewhat influenced by your muscular bodyweight - i.e. the bigger you are the more you are going to need. The recommended dosage is around 3 - 5 grams per day. With most companies that have brougt a good quality ethyl ester product to the market - the capsules are around 1g each and so you will be consuming around 3 - 5 capsules per day. This is best to take with water and around 30 minutes prior to a meal to enhance absorption. There are no immediate benefits of note to take the product immediately prior to a training session or post training and likewise no negatives to doing this.

Unlike Monohydrate there is no evidence to suggest that the best thing to do is to cycle ethylated creatine ester. One could use this supplement long term without a break although there would probably no benefit to the psychological boost experienced, when initially supplementing with a creatine product.

As stated, due to the enhance lipopholic absorption of the esterified creatine there is absolutely no need to load up on this compound.

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