Also Known As:
7-OXO-DHEA
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Variations:
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Related
Items:
DHEA |
Type:
Pro-Hormone (DHEA-Derivative)
Anti-Catabolic |
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WHAT IS 7-KETO?
7-Keto improves lean body mass by reducing
cortisol and increasing testosterone-to-cortisol ratios enabling the body to
build muscle in a growth promoting environment. It has also been shown to
increase your body's ability to burn calories. It is a non-hormonal,
non-androgenic derivative of DHEA.
The groundbreaking new micronutrient 7-Keto, a patented compound which, by
activating thermogenic enzymes, has been shown to safely increase the basal metabolic rate and thus "burn"
calories more rapidly and continually throughout the day, even while resting, as
well as inhibit the storage of fat within the body.
HOW DOES 7-KETO WORK?
When we age the ability to control our quality of life becomes an issue for all
of us. The application of aging research into the steroid dehydroepiandrosterone
(DHEA) has helped our understanding of age induced losses of functional
capacity, and has subsequently lead to the discovery of a relatively new
compound "7-OXO-DHEA".
7 - Keto as it is more commercially known may have physiological actions that
allow us to train well into old age. Recent studies suggest it may also have
applications to a youthful, healthy, and physically active population. So the
questions beckon; is there evidence to support 7-keto use over a broad spectrum
of ages? And if so, how can it affect our physiques? And what lessons can be
learnt from ageing science to keep us ahead of the dietary supplement market
regarding the use of this novel compound?
The appliance of science to any functional context, in this case your health,
performance and physique goals, are the mark of any good nutritional scientist.
But as a scientist you can only base your assumptions on the scientific facts
and fortunately for us this month we have plenty to work with; as the discovery
of the DHEA metabolite "3b -Acetoxyandrost - 5 - ene-7, 17- dione" was
discovered back in the late 1950's.
Because of this we have amassed a large volume of work in this often heavily
chemical orientated, and sometimes confusing area of metabolism. In the past,
7-keto's closest relative DHEA gave us the initial and indeed pioneering
insights into the potential benefits this class of compound can deliver.
Clinical conditions such as: insulin resistance, cardiovascular disease,
osteoporosis, and age-induced sarcopenia all have been positively influenced by
the use of DHEA.
Although considered relatively inert by the mid to late 90's, this view on
DHEA was in for a radical change. The National Institute of Aging issued a
public service announcement regarding its safety and warned consumers of its sex
steroid associated side effects. Because of the potential benefits to health,
the search for a DHEA-like compound without the associated side effects was on.
Although first identified in human urine in 1948 and tissues in 1954 it wasn't
until the mid 90's when Dr. Henry Lardy began the excellent research on what he
called "Ergosteroids".
The nomenclature of the ergosteroid family emerged due to their influences on
energy metabolism; indeed this area in particular will form the core of our
discussion on 7-keto. After a paper was released showing that DHEA could bring
about a thermoginetic effect in rats, it wasn't long before both the
nutraceutical and scientific world began the search for an effective and
"safe alternative to ephedrine" for fat loss. In essence, a chemical
that could confer the positive health benefits of DHEA.
DHEA is a steroid produced by the adrenal gland and is the most abundant
steroid in human blood. There are always two things you should understand prior
to the use of any sport / health supplement.
- Safety of the product and the dose range proven to be safe.
- Knowledge of how the supplement is taken up into the tissues and how quick
it is excreted, "in-essence it's pharmacokinetic profile".
7-keto is a highly active derivative of DHEA and is one supplement of which
its pharmacokinetic profile is needed if we want to ascertain when peak levels
occur in plasma. This information will help prescribe the best possible rational
for its time of use, dosage, and safety to optimise body compositional changes.
A series of trials have looked at both the safety and pharmacokinetics of
7-keto. In animal studies, 7-Keto was shown to be safe and in effect non-toxic
to levels of 2000mg/kg in rats and 1000mg/kg in monkeys. Toxicity was assessed
by full-blood chemistry, blood cell counts and histological examination in 42
different tissues. Again caution must be taken until we see the human data; so
what human data does exist? Davidson et al studied a series of doses ranging
from 50mg/d (25mg twice daily) for 7 days; 100mg/d (50mg twice daily) for 7
days; and finally 200mg/d (100mg twice for 28 days). Results demonstrated that
at all doses, 7-keto in comparison to a placebo presented no substantial impact
on clinical blood markers of toxicity and health. This data was supported in
further human trials.
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