Also Known As:
19 Norandrostenedione
19 Norandrostenediol
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Variations:
19 Nor Cyclo dione
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Related
Items:
Cyclodextrin
Testosterone |
Type:
Pro-hormone |
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WHAT IS 19 NOR?
19 Nor is a commonly used name for a group of prohormones that includes two
slightly different prohormones,
19 Norandrostenedione and
19 Norandrostenediol. Both of these substances are converted in the liver to
nandralone, a blend of testosterone whose affects upon the body increase protein
synthesis - a buildup of muscle tissue, possible aggression, hightened strength
levels and possibly an ability to lower body fat levels. Whilst the 19 Nor Diol version is thought to have a better
conversion rate, 19 Nor Dione is thought to have better bioavailability. In
essense both products seem about equal in their effectiveness to convert to
nandralone.
HOW DOES THIS SUBSTANCE WORK?
Taken orally
19-nor-4-androstendione or 19-nor-4-Androstendiol (norandrostendione - similar
to chemical structure of androstendione/diol, minus the methyl group at the 19th
position) convert in the liver to nortestosterone instead of testosterone. This
conversion uses the 17-beta-hydroxysteroid dehydrogenase enzyme which is the
same enzyme used by the body to convert androstendione to testosterone.
Nortestosterone has strong
anabolic properties with less androgenic properties.
THE DIFFERENCE BETWEEN
ANABOLIC AND ANDROGENIC
Testosterone is the primary male
sex hormone which is manufactured in the lydig's cells of the testes at varying
amounts throughout a persons life - typically between 2.5mg and 11 mg for a male
and about 1/4 of a mg for women daily. Increasing in boys during puberty and
tapering off to lower amounts later in life. Androgenic properties of this
hormone include a deepened voice, body and facial hair growth, increased oil
output by the subaceous glands, development of sexual organs, maturation of
sperm and an increased libido. These being the main underlying effects
differenciating men from women, whose primary sex hormone is estrogen which has
very different effects upon the body.
The anabolic effects of
testosterone produce growth promoting changes such as an enhanced rate of
protein synthesis which leads to accumulation of muscle tissue and increased
calcium retention in bones. Testosterone also increases the production rate of
red blood cells. which increases the transport of oxygen around the body.
Hormones are secreted and are
circulated around the body via the blood stream. Once they find receptor sites
for their hormone they interact with that specific cell and cause the desired
cellular effect by passing on the message to the cells nucleus. Once this
operation is complete the testosterone molecule is freed up to circulate once
more in the blood stream. If you imagine a lock and a key, we liken hormone and
receptor sites to this principle. Only the specific key will lock into the
specific key hole. With testosterone this typically means the androgen receptor
sites located at several body tissues including skeletal muscle tissue.
Testosterone has a strong
anti-catabolic effect. Cortisol - the bodies primary stress hormone sends the
opposite message to muscle cells - to release protein. This is the bodies
usual response to maintain homeostasis - equilibrium. Our bodies don't typically
like change - this is why is often hard to loose fat and hard to gain muscle.
However anything that allows a lower catabolic environment and a higher anabolic
enviornment is the key to increasing muscle and burning fat.
ANDROGENS AND ATP
As well as increased protein
synthesis a higher androgen level enhance production of creatine phosphate which
plays a vital role in the production of the muscles primary fuel for contraction
- ATP (adenosine tripohosphate). As muscles are stimulated to contract ATP is
broken down into ADP (adenosine diphosphate), which releases energy. The cells
then undergo a process using creatine phosphate to rapidly restore ADP to it's
original structure in order to replenish ATP concentrations. During periods of
intense training however this process is not fast enough to compensate and ATP
levels will be lowered causing the muscles to fatigue and less able to effort a
strenous contraction. With increased levels of CP available to the cells, ATP is
replenished at an enhanced rate and the muscle is both stronger and more
enduring. This is another reason for increased strength from a substance that
increases testosterone.
SIDE EFFECTS FROM 19-Nor BASED
PRODUCTS
As stated earlier 19-nor converts
into nortestosterone rather than testosterone. With this being the case we find
relatively few side effects. Nortestosterone binds to testosterone receptor
sites and elcits good protein building and sparring effects, however there is no
rise estrogen and so no water retention or fat storage should be noticed. The
oil glands are typically not stimulated highly and there is little chance of any
prostate enlargement or hair growth/loss etc. This makes 19-nor probably one of
the safest, naturally occuring substances to elicit similar effects to steroids
legally available.
HOW MUCH AND WHEN?
Effective dosages of 19 Nor are generally regarded as being around 200mg per
day (although the cyclodextrin versions require dosages of only around a tenth
of this).
19 Nor is best taken first thing in the morning to coincide with the bodies
natural high levels of hormone. It is also suggested that taking them around 60
minutes before training is advantageous, both for strength and coinciding with
natural hormone highs achieved during brief intense training.
19 Nor is effective for women, and has no androgenic properties. (ie
masculinating).
A NOTE ON CYCLODEXTRINS
Cyclodextrin based 19 Nor has become very popular. A cyclodextrin is a
form of carbohydrate bound to fat soluble compounds, that can be absorbed through the cavity membrane under the tongue,
transporting whatever it has been bonded with straight into the blood stream.
This technique is used in the medical world for drug transportation.
Cyclodextrins therefore cause the 19 Nor to bypass the digestive system,
resulting in a 900% better absorption rate. Allowing smaller doses to be taken
to give a good effect.
CHECK WITH A PHYSICIAN
As with any prohormone an alteration of ones own endocrinal system may be
altered. For this reason it may be of importance for some to do a little extra
research into these compounds before taking them or even checking with a
physician to have a checkup or blood chemistry analysis before embarking a
course of prohormones.
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