[LG Sciences] Ghenerate

Legal Gear (L.G. Sciences) are fully aware of the incredible effects growth hormone (GH) has on the body.

Many bodybuilders will inject the GH to achieve the following:
* more resilient to damage connective tissue, ligaments and tendons
* increase muscle mass dramatically
* reduce bodyfat
* healthy skin and hair
* supremely fast recovery from training and injuries.

Unfortunately HGH (Human Growth Hormone) is illegal and so experiencing these incredible benefits means you will have to maximise your bodies ability to generate as much GH as possible.

Ghenerate has the ability to stimulate the GHSR (Growth Hormone Secretagogue receptor) thanks to the peptide marus alba extract. This mimics the effects of GHRP and it's natural analog ghrelin, claiming to be as effective as GHRP-2. This exciting compound has been shown make large increases in growth hormone, up to 12 times the baseline.

Peurariae Radix is a plant that has the compound peurarin present in it. This compound has an ability to increase GH levels by up to 520% as well as being a natural phosphoinositol 3 kinase stimulator which is the same anabolic pathway stimulated by IGH-1 and insulin to load muscles full of glycogen.

This GH releasing supplement is different from IGH-1 (another L.G. science growth hormone supplement) as IGH-1 reduces somatostatin. Somatostatin is the natural hormone your body produces to reduce GH production, therefore blocking it will result in larger amounts of Growth Hormone.
Armed with this knowledge the two Ghenerate and IGH-1 would stack together incredibly well leading to exponential results and huge surges of growth hormone!
 

Why the world needs a GREAT GH supplement!

My parents are getting a little on in years and growth hormone replacement therapy is all the rage right now. I wanted to help get my parents a great GH product that worked. Sadly, I didn't see my mom injecting herself every day in order to look younger. I had read about GHRP-2 and GHRP-6 and I was intrigued. They show great promise in the literature! Unfortunately, these two peptide hormones are sold as injectibles. I thought that maybe I could try them under the tongue to get penetration and to my pleasant surprise, there was some serious potential there. I was certainly not going to give her some homeopathic "GH" or deer velvet that I knew didn't work and quite frankly pissed me off.

I started looking heavily into growth hormone release and I saw that there are two main pathways. The first I've discussed, which is the GHRP pathway or the Growth Hormone Secretagogue receptor. Ghrelin and GHRP-6/GHRP-2 stimulate this. This pathway is very potent at releasing GH and is a good route, yet there are more potent routes of growth hormone release which is why we needed a two- phase technology to get the job done.

Unfortunately, GHRP-2 and GHRP-6 are illegal to sell in the US, since they are drugs and 100% synthetic. So, I started looking in the literature for NATURAL versions of GHRP to use. Luckily, I found a peptide in the fruit of Marus Alba that mimic's the effect of GHRP and it's natural analog Ghrelin (2). This was an amazing find! I could now legally sell a supplement that had the same effect as GHRP-2 without being illegal! Understand, that this peptide is not Ghrelin, but does exactly what synthetic peptides like GHRP-6 and GHRP-2 do, stimulate the GHSR receptor! Amazing find, but I couldn't stop there.

GHRH is the other receptor that allows for LARGE increases in growth hormone (up to 12 times baseline). By stimulating this receptor you cause massive spikes in circulating GH. Luckily, we found an amazing GHRH stimulating supplement that I included in GHenerate to boost growth hormone levels even higher. This pathway is totally new to the sports supplement world and the next paragraph details the GHRH agonist I found!

Puerariae Radix is a plant that has one particular constituent that is set to be the next superstar. It is called puerarin! Puerarin is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. This ingredient was an amazing find but the key is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is a HUGE increase and shows that this second pathway is very potent at releasing GH. We use only 98% pure puerarin complexed with cyclodextrin in our formula so it is ultra potent. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, just a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by IGF-1 and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity! Jackpot!

These two ultra potent pathways are what give GHenerate the amazing body recomp, appetite increasing effects that were experienced by our testers and make it the most potent GH secreting agent ever produced. One tester gained 8lbs on GHenerate alone, which is unheard of for a GH product. There is nothing on the market like GHenerate!

What about IGH-1? Luckily IGH-1, our GH secretagogue works in a totally different manner, which is to reduce somatostatin, meaning it will enhance and increase the potential of GHenerate. Somatostatin is the natural hormone your body produces to reduce GH production, so blocking this is a very good thing to do with GHenerate, so stacking the two is going to give exponential results.

While these studies are not conclusive, we just couldn't wait for years of clinical data on these ingredients to bring the product to market. We are looking into doing studies on all aspects of GH release with this product. We felt compelled to offer this product to people who like the science and wish to be early adopters to this new experience and see the value in the preliminary data and anecdotal experiences of our testers.


Preliminary clinical trial confirms data showing GHenerate with IGH-1 increase growth hormone by up to 5834%



In a landmark, groundbreaking preliminary clinical trial 3 healthy humans wanting to optimize their growth hormone levels, used a protocol of LG Sciences IGH-1 and GHenerate to increase their growth hormone levels. The three patients under medical care used the supplements in a

5 on 2 off protocol taking the supplements as directed before noon and prior to bed. These amazing results were called "outstanding" by Dr.

Margolis, who supervised the tests. The testing protocol quantified 24 hour growth hormone levels in the urine, which is considered the "best"

method for calculating growth hormone. The initial pg/24hr measurements for the three patients was 436, 676 and 169 pg/24 hours and the final results were 801, 2694 and 9850 pg/24 hours. Giving outstanding results. The averaged increase was 1042% for the group and larger clinical studies are planned. This study partially confirms the preliminary rodent data that was the inspiration for the two supplements. Ghenerate contains a patent pending blend of Puerarin and Marus Alba extract which both show potential for growth hormone potentiation. IGH-1 contains a blend of ingredients shown in the literature to potentially reduce somatostatin levels which works in a synergistic way with GHenerate to increase Growth Hormone levels.



Reference Studies:
1) Horm Metab Res. 2004 Feb;36(2):86-91. Induction of growth hormone release by Pueraria thunbergiana BENTH. Jung DY, Ha H, Kim C. Drug Research and Development Team, Korea Institute of Oriental Medicine, 129-11 Chungdam-dong, Kangnam-ku, Seoul 135-100, Korea.

Puerariae Radix (PR), Puerariae Flos (PF), and Puerariae Surculus (PS) as well as their constituents were tested for induction of rat growth hormone (rGH) release by both rat pituitary cell culture and in vivo experimentation in order to develop them to novel drugs. Through a calibration curve of the rGH released by addition of rat growth hormone-releasing hormone (rGHRH) to rat pituitary cells, the 70 % ethanol extracts of PR and PS increased rGH release by about 1.6 and 1.7 times as high, respectively, as the control group (264.6 +/- 13.6 pM). However, each puerarin type as a representative constituent of PR in Korea Pharmacopeia (KP) and tectorigenin and an important ingredient of PF were twice as effective as in the control group. The acid hydrolysate of Puerariae Surculus (HPS) increased rGH release concentration-dependently, and its EC (50) was approximately 10.4 microg/ml. The T (max) value for rGH after injection of 20 microg/kg of rGHRH was 10 - 30 min, while the C (max) value was increased by approximately 12-fold compared to the control group (198.2 +/- 25.0 pM) and the AUC (0 - 45) was increased to 10 times the level of the control group (10,840.9 +/- 845.5 min. pM). On the other hand, T (max) for the HPS was 60 min, while C (max) was increased approximately to 5.8 fold compared to control (244.1 +/- 36.4 pM). C (max) for puerarin was 1,028.6 +/- 502.7 pM, that is, approximately 5.2 times as high as the control level. However, tectorigenin (20 microg/kg) was of no statistical significance. Therefore, we suggest that the HPS and puerarin act either on GH secretagogue receptors or on GHRH receptor of somatotrophin as possible agonists or an inhibitor on somatostatin receptor to release rGH, respectively.

2) Peptides. 2006 Jul;27(7):1597-602. Epub 2006 Feb 17. Ghrelin in plants: what is the function of an appetite hormone in plants? Aydin S Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.

In the present work, we provide compelling evidence for the expression of a ghrelin-like peptide hormone that has only been associated with animals, in various plant tissues. Ghrelin, the appetite stimulating hormone, has been identified from a number of different species including humans, rat, pig, mouse, gerbil, eel, goldfish, bullfrog and chicken. The study here was conducted using an immunohistochemistry assay to screen whether plants have any ghrelin immunoreactivity. In this respect, Prunus x domestica L. and Marus alba were examined. Immunohistochemistry results showed that there is a strong human ghrelin immunoreactivity substance in the parenchyma cells of these plants. This was entirely unexpected since this hormone was considered to be present solely in animals. Thus, this study is the first to report the presence of a peptide with ghrelin-like activity in plants, a finding that has only been observed in the animal kingdom. RIA analysis confirmed that these plants contain significant amounts of this substance. Furthermore, reverse-phase HPLC analyses of plant extracts showed an elution characteristic of the peptide identical to that of human ghrelin. In general, fruit from both plants had higher levels of the peptide than the vegetative parts.

3) Food Chem Toxicol. 2008 Dec;46(12):3671-6. Epub 2008 Sep 23. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Li Y, Chen H, Yang S, Xie G. Cancer Hospital of Tianjin, Tianjin Medical University, Ti-Yuan-Bei, Tianjin 330060, China. liyanwei127@hotmail.com

4) Toxicol Appl Pharmacol. 2008 Dec 15;233(3):371-81. Epub 2008 Sep 19. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Hwang YP, Jeong HG.