[iSatori] 3-XL

Respect. It doesn't come easy. You have to earn it... By gritting out rep after rep in the gym. In your quest for heroic biceps, bowling-ball shoulders, and an extra wide back. Bottom line: You have to make the most of every workout. That's where Isatori 3-XL comes in.

Isatori 3-XL (formerly called Isatori CE-XL) is the most advanced creatine ester formula developed. Engineered to deliver more increases in muscular size and strength than anything you've ever tried before. Within one week, you'll experience greater muscular fullness, crush your current training plateaus, and carry a "pump" around the gym that makes other guys seethe with envy.

Increase Muscular Strength, Size, and Hardness
Generate Increased Blood Flow and Muscular Fullness
Increase Muscle Cell Volumization
Maximize Total Power Output
Enhance Muscle Fiber Recovery
Creatine Monohydrate: One of the most widely used performance-enhancing supplements on the market, creatine has been the subject of over 200 studies. These studies have shown definite positive effects for muscle building, enhanced cellular energy capacity, and reduced muscle fatigue. Beyond its muscle-building and performance-enhancing effects, creatine has been shown to increase fat loss and have positive effects on overall health by reducing cholesterol and triglyceride levels and improving blood-sugar metabolism.

One of the most thoroughly tested dietary supplements overall, and perhaps the most exhaustively tested sports nutrition ingredient outside of carbohydrates, is creatine monohydrate. Until several studies show that a different form of creatine is superior to creatine monohydrate when it is directly compared to creatine monohydrate, and that "superiority" is defined by significantly greater increases in fat-free mass and/or muscular performance, creatine monohydrate stands alone.

*Di-Creatine Malate: A highly soluble creatine salt thought to provide a greater increase in creatine bioavailability over regular creatine monohydrate. Quite simply, this compound is creatine bound to malic acid. Malic acid is a naturally occurring Krebs Cycle intermediate, meaning that malic acid plays a crucial role in our natural energy cycle. Malic acid, coupled with creatine, as in Di-Creatine Malate, offers much greater ATP production over conventional creatine monohydrate. In the body, malic acid...

Stimulates oxygen consumption by increasing mitochondrial uptake of other substrates
Is the only metabolite of the Krebs Cycle that falls in concentration during exhaustive physical activity
Depletion has been linked to physical exhaustion
Supports the removal of components that buildup under hypoxic conditions and inhibit ATP production.
*Creatine Ethyl Ester or CEE is a membrane permeable form of creatine that theoretically can enter the cells without having to use the "typical" creatine transporter molecules. Creatine Ethyl Ester HCL (CEE) is creatine monohydrate with an ester attached. Esters are organic compounds that are formed by esterification—the reaction of carboxylic acid and alcohols. Users are reported to gain substantial increases in strength and muscle mass, with none of the gastrointestinal discomfort or water bloating normally associated with the monohydrate form. Recommended dosages range from as little as one to three grams per day with no "loading" phase, as typically prescribed for the monohydrate form. Creatine monohydrate is semi-lipopholic (which means it inefficiently uses fat as a transport mechanism). The esterification of substances increases their lipopholic abilities, leading to the conclusion that esterified creatine will use fat more efficiently to permeate the cell wall and have greater benefits upon cellular function than creatine monohydrate alone.

*Elemental Creatine Transporter Cofactors: Sodium and Chloride Creatine transporters, as stated above, also localize in the intestines and thus are the "first line" of creatine transport. Because of the not uncommon experience of intestinal distress (loose stools, diarrhea) among a minority of creatine users, especially during the loading phase, one wonders whether optimizing creatine transport conditions within the gut could make a distinctively positive difference.

Using animal intestinal segments and cells, intestinal creatine transport has recently been shown to have a critical requirement for a specific ratio of sodium and chloride ions—a 2:1 ratio—and no apparent requirement for potassium.

Because creatine transporter proteins are sodium- and chloride-dependent transporters, the provision of an optimal ratio of sodium and chloride, but not at an amount posing a concern for sodium-sensitive individuals, may foster greater gut tolerability during loading or single high-dose creatine monohydrate supplementation. Additionally, this transporter cofactor ratio may push absorption to the theoretical maximum of 100% of an oral dose.

*Histidine is an amino acid found in the proteins of all life forms. Although most L-histidine is found in proteins, a small amount of free L-histidine does exist in plants and fermented foods. The naturally occurring dipeptides found in muscle, carnosine and anserine, are both comprised of L-histidine and beta-alanine. At the very least, it is a conditional essential amino acid for adults. That is, even though L-histidine is synthesized in adult human tissues, sufficient quantities may not be made to meet the physiological requirements imposed by certain stress or disease situations.

It is also interesting to note that histidine alone increases nitric oxide (NO) 48% more than an equivalent concentration of arginine. So the use of an arginine and histidine mixture may be the most financially viable NO-releasing combination on the market today.

*Di-Arginine Malate is a novel compound featuring two molecules of L-arginine bound to malic acid. Most available NO boosters offer only one molecule of L-arginine bound to AKG. L-Arginine is thought to increase nitric oxide production, leading to increased vasodilation and potentially increased protein synthesis. The positive effects of L-arginine on nitric oxide production are well established, but there were no published studies regarding arginine alpha-ketoglutarate and nitric oxide production.

Di-Arginine Malate™ was created by combining arginine with malic acid, a naturally occurring intermediate in the Krebs Cycle. This bond makes much more sense because malic acid is the only metabolite of the Krebs Cycle that falls in concentration during exhaustive physical activity. Studies show that malic acid stimulates oxygen consumption by increasing mitochondrial uptake of other substrates, and it's also known to support the removal of components that buildup under hypoxic conditions and inhibit ATP production.

What is 3-XL?
3-XL is an advanced Tri-STRENGTH Creatine Complex™, developed by the researchers at iSatori, to help increase muscular size, strength, and hardness.

How does 3-XL work?
3-XL is engineered to improve the absorption and retention of creatine, using a combination of three different creatines, including a novel form of creatine ethyl ester hydrochloride. Creatine ethyl ester, in combination with its bioactive agents, and a unique delivery method called Accelerated Plasma Shuttle Technology™, found only in 3-XL, will dramatically improve total muscular output and increase muscle mass, strength, and hardness. For those seeking the most advanced results possible with 3-XL, iSatori's researchers also recommend using H+Blocker™, the new beta-alanine/carnosine synthesizer, to maximize gains.

What kind of results can I expect from using 3-XL?
Although it's impossible to say exactly how much muscle size and strength each person will gain from using 3-XL—obviously, as individuals differ, so will results—it is not unheard of for individuals to experience immediate strength gains, muscle fullness, and noticeable lean body mass gains within the first five days. More notably, though, unlike conventional creatine monohydrate alone, which has to be "loaded" and then "cycled," 3-XL can be used continuously, thereby allowing users to continue to experience results for as long as they use the supplement.

What's inside 3-XL?
The combination of active compounds, found only in 3-XL, is called the Tri-STRENGTH Creatine Complex™. This is an exclusive blend of creatine ethyl ester, creatine monohydrate, and di-creatine malate, which are the most superior forms of creatine substances available. To that, di-arginine malate was added as a natural biological precursor for nitric oxide, to aid in the delivery of creatine and improve blood flow. 3-XL also contains a precise blend of histidine, carbohydrates, sodium, and chloride to aid in the rapid transport of the nutrients into the muscular plasma and enhance creatine absorption and storage even higher.

Why is 3-XL better than regular creatine monohydrate?
Keep in mind, 3-XL contains some creatine monohydrate, along with di-creatine malate. However, using only the purest esterfied form of creatine (creatine ethyl ester hydrochloride), combined with these two other forms of creatine in the Tri-STRENGTH Creatine Complex™, 3-XL is engineered to improve the effects of creatine and eliminate all of the unwanted, common "side effects" of conventional creatine forms. In other words, with 3-XL, you can expect:

Creatines to transport faster and more efficiently (up to 10 times faster), because of their lipopholic abilities, which allows them to use fat more efficiently to permeate the cell wall and exert its effects upon cellular function.
No "loading" is required because more of the creatine is absorbed, and the optimal dose needs to be taken only once daily.
Typically, creatine ethyl ester works for most creatine "non-responders."
Virtually no water retention occurs outside of the target muscle cells, thereby eliminating the infamous "creatine bloat."
How do I take 3-XL for optimal results?
As the label recommends, consume one serving (a single scoop) of Fruit Punch flavored 3-XL mixed with eight ounces of water, about 30 minutes immediately following intense exercise or physical activity. On non-training days, consume one serving following your morning or afternoon meal. Remember, as with all supplements, "more is better" is not always a good idea. 3-XL is engineered to work with a single dose taken each day.

Do I need to "load" or "cycle" 3-XL?
Loading is not necessary. Relative to cycling, although there is no need to "cycle" 3-XL, as we recommend with all supplements, it's suggested that users follow an eight- to 12-week "on" period followed by a two- to four-week "off" period. It's always a good practice to cleanse the body and help it respond more optimally to supplement usage again, once it's resumed.

Can I take 3-XL with a creatine supplement?
No. It's not necessary. However, for those seeking the most advanced results possible with 3-XL, iSatori's researchers also recommend using H+Blocker™, the new beta-alanine/carnosine synthesizer, to maximize gains.

Are there any known side effects?
There are no known negative side effects. In fact, the active compounds in 3-XL are produced in the body, are naturally found in small amounts within meats such as beef, and have been tested in animals and humans quite extensively with no adverse effects. Remember, it's always a good idea to check with your doctor first before starting any new diet or exercise plan. And please read the label carefully before you begin use.

WARNING Isatori 3-XL is not intended for individuals under the age of 18 unless instructed by a doctor. Do not use this supplement if you are pregnant, nursing, or contemplating pregnancy. If you, or your doctor, have any questions about this supplement, please call 1-303-215-9174. Keep out of reach of children.